How different oncogenic events interact during hepatocellular carcinoma (HCC) initiation.

To date, mouse models of HCC do not accurately replicate the molecular development of human liver cancer, a problem that presents an obstacle to fully understand the complex mechanisms of human HCC and poses a limit to the development of novel therapeutic approaches. We are combining mouse genetics with the use of transposons to better replicate the initiation of HCC as it develops in humans, as well as the interactions between different oncogenic mutations.