FONT-BURGADA LAB

 

PUBLICATIONS

Strathearn LS, Stepanov AI, Font-Burgada J. "Inflammation in Primary and Metastatic Liver Tumorigenesis-Under the Influence of Alcohol and High-Fat Diets".

Nutrients 2020 Mar 27;12(4). pii:E933. doi: 10.3390/nu12040933. PubMed

 

Beauchemin L, Slifker M, Rossell D, Font-Burgada J. "Characterizing MHC-I Genotype Predictive Power for Oncogenic Mutation Probability in Cancer Patients".

Methods Mol Biol. 2020;2131:185-198. doi: 10.1007/978-1-0716-0389-5_8. PubMed

 

Wong J, Garcia-Carbonell R, Zelic M, Ho SB, Boland BS, Yao SJ, Desai SA, Das S, Planell N, Harris PA, Font-Burgada J, Taniguchi K, Bertin J, Salas A, Pasparakis M, Gough PJ, Kelliher M, Karin M, Guma M. "RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-KB Activation".

Cell Mol Gastroenterol Hepatol. 2020;9(2):295-312. doi: 10.1016/j.jcmgh.2019.10.002. Epub2019 Oct 10. PubMed

 

de Prisco, N, Stout E, Font-Burgada J. "Specific labeling and lineage tracing of periportal hepatocytes using two-step genetic recombination".

Methods Mol Biol. 2019;1905:59-70. doi: 10.1007/978-1-4939-8961-4_6. PubMed

 

Marty P R, Thompson WK, Salem RM, Font-Burgada J, Zanetii M, Carter, H. "Evolutionary pressure against MHC class II binding  cancer mutations."

Cell. 2018 Oct 4;175(2):416-428.e13. doi: 10.1016/j.cell.2018.08.048. Epub 2018 Sep 20. Erratum in: Cell. 2018 Dec 13;175(7):1991. PMID: 30245014. PubMed. Correction.

 

Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M#, Carter H#, Font-Burgada J#. “Intergrative genomic analysis of mouse and human hepatocellular carcinoma”. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9879-E9888. doi:10.1073/pnas.1811029115. (# co-corresponding authors). PubMed

 

Marty R, de Prisco N, Carter H#, Font-Burgada J#. “MHC-I genotype drives early immune selection of oncogenic mutations”.

Mol Cell Oncol. 2018 Jan 25;5(2):e1409863.doi: 10.1080/23723556.2017.1409863. (# co-corresponding authors). PubMed

 

Marty R, Kaabinejadian S, Rossell D, Slifker M, van der Haar J, Engin HB, de Prisco N, Ideker T, Hildebrand WH, Font-Burgada J#,*, Carter H*. “ MHC-I genotype restricts the oncogenic mutational landscape”.

Cell. 2017 Nov 30;171(6):1272-1283.e15. doi: 10.1016/j.cell.2017.09.050. (#corresponding author, *equally contributed). PubMed

 

Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, Yamaguchi K, Koike K, Itoh Y, Diaz-Meco MT, Moscat J, Karin M. “p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells”.

Cancer Cell. 2016 May 19; doi: 10.1016/j.ccell.2016.04.006. [Epub ahead of print]. PubMed

 

Font-Burgada J, Sun B, Karin M. “Obesity and cancer: The oil that feeds the flame”.

Cell Metabolism. 2016 Jan 12; 23(1):48–62. doi: 10.1016/j.cmet.2015.12.015. PubMed

 

Wree A, Johnson CD, Font-Burgada J, Eguchi A, Povero D, Karin M, Feldstein AE. “Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation”.

Cell Death Differ. 2015 Dec;22(12):1985-94. doi: 10.1038/cdd.2015.46. PMID: 25909884. PubMed

 

Font-Burgada J#, Shalapour S, Ramaswamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M#. “Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer”.

Cell. 2015. Aug 13;162(4):766-79. doi: 10.1016/j.cell.2015.07.026. PMID: 26276631. (# co-corresponding authors). Highlighted in Cell Stem Cell (2015 Oct 1;17(4):377-8) and Nature Reviews Gastroenterology and Hepatology (2015 Oct;12(10):549) PubMed

 

Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D, Willimsky G, Ammirante M, Strasner A, Hansel DE, Jamieson C, Kane CJ, Klatte T, Birner P, Kenner L, Karin M. “Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy”.

Nature. 2015 May 7;521(7550):94-8. doi: 10.1038/nature14395. PMID: 25924065. PubMed

 

Kessler R, Tisserand J, Font-Burgada J, Reina O, Coch L, Attolini CS, Garcia-Bassets I, Azorín F. “dDsk2 regulates H2Bub1 and RNA polymerase II pausing at dHP1c complex target genes”.

Nat Commun. 2015 Apr 28;6:7049. doi: 10.1038/ncomms8049.PMID: 25916810. PubMed

 

Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle N, Wu LW, Yang J, Dowdy SF, Reya T, Karin M. “Ubc13 Controls Breast Cancer Metastasis through a TAK1-p38 MAP Kinase Cascade”.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13870-5. doi: 10.1073/pnas.1414358111. PMID: 25189770. PubMed

 

Nakagawa H*, Umemura A*, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M (2014). “ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development.”

Cancer Cell. 2014 Sep 8;26(3):331-43. doi: 10.1016/j.ccr.2014.07.001. PMCID: PMC4165611 (*co-first authors). PubMed

 

Nakagawa H*, Hikiba Y*, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano K, Ikenoue T, Ijichi H, Dhar D, Shibata W, Akanuma M, Koike K, Karin M, Maeda S. (2014) “Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis.”

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1090-5. doi: 10.1073/pnas.1322731111 PMCID:PMC3903249 (*co-first authors). PubMed

 

Font-Burgada J*#., Reina O*, Rossell D#, Azorin F# (2014). “chroGPS, a global chromatin positioning system for the functional analysis and visualization of the epigenome.”

Nucleic Acids Res. 2014 Feb;42(4):2126-37 doi: 10.1093/nar/gkt1186 PMCID: PMC3936722 (*co-first authors. #co-corresponding authors.) Selected as cover article. PubMed

 

He G*, Dhar D*, Nakagawa H*, Font-Burgada J*, Ogata H*, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K and Karin M (2013). “Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling”.

Cell. 2013 Oct 10;155(2):384-96. doi: 10.1016/j.cell.2013.09.031 PMID:24120137 (*co-first authors). Highlighted in: Nature Medicine 2013 19(11):1376. PubMed

 

Font-Burgada J., Seki, E., Karin, M. (2012). “CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction”.

Cancer Cell. 2012 Jun 12;21(6):711-2. doi: 10.1016/j.ccr.2012.05.034.PMID:22698394. PubMed

 

Font-Burgada J, Rossell D, Auer H, Azorin F (2008). “Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression”.

Genes & Dev. 22(21): 3007-3023. doi: 10.1101/gad.481408 PMCID: PMC2577788. PubMed